No dose adjustment is needed in patients with HCV infection. There were 2 opioid-tolerant subjects in the low intravenous buprenorphine group , 3 in the mid BUP group , and 3 in the high BUP group . The numbers in parentheses represent the geometric mean of buprenorphine plasma concentrations in each group from 2 hours to 6 hours after infusion onset. The escalating fentanyl doses 1 to 4 were 0.25, 0.35, 0.50 and 0.70 mg/70 kg body weight. The same subject in the low BUP group had apnea after the third and fourth fentanyl boluses.
Buprenorphine is sought by people with opioid use disorder and is subject to criminal diversion. Monitor all patients for progression of opioid use disorder and addictive behaviors . Neonatal opioid withdrawal syndrome is an expected and treatable outcome of prolonged use of opioids during pregnancy . For mild symptoms of an allergic reaction, call your doctor right away.
What should I know about Sublocade vs. Vivitrol?
St. John’s wort can reduce the level of buprenorphine in your body. (Buprenorphine is the drug in Sublocade.) This could make Sublocade less effective or cause withdrawal symptoms. Avoid taking opioids while you receive Sublocade and for a few months after you stop Sublocade treatment. You should use an opioid pain reliever only if your doctor has prescribed it and knows that you’re receiving Sublocade.
Here’s a short list of some of the mild side effects that Sublocade can cause. To learn about other mild side effects, talk with your doctor or read Sublocade’s medication guide. Tell your doctor if you’re having any withdrawal symptoms after stopping Sublocade. Yes, I would like to receive my results or other information related to my search using the Find a SUBLOCADE samhsas national helpline Treatment Provider Tool and some resources that may help in a discussion with a healthcare provider . Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. You may have detectable levels of SUBLOCADE in your body for a long period after stopping treatment with SUBLOCADE.
How Sublocade is given
Inform patients that SUBLOCADE can cause drug dependence and that withdrawal signs and symptoms may occur when the medication is discontinued . Educate patients and caregivers on how to recognize the signs and symptoms of an opioid overdose. Buprenorphine is a partial agonist alcohol addiction treatment center at the mu-opioid receptor and chronic administration produces physical dependence of the opioid type, characterized by withdrawal signs and symptoms upon abrupt discontinuation. The withdrawal syndrome is milder than that seen with full agonists and may be delayed in onset .
Should’ve never listened to them, feel like I was setup to fail. It has potential for misuse and can cause physical and psychological dependence. Patients who are prescribed buprenorphine should be monitored for diversion, misuse, and addictive behaviors. Age, sex and race do not significantly affect the pharmacokinetics of buprenorphine.
So there’s very little chance that anyone else could obtain the drug and misuse it. In the same study, fatigue was reported in 3.9% of people who took 300 mg of Sublocade, followed by 100 mg of Sublocade once a month. Fatigue occurred in 6% of people who took 300 mg of Sublocade throughout the study. Serious side effects from Sublocade aren’t common, but they can occur. Call your doctor right away if you have serious side effects.
You can start using Sublocade once you’ve received treatment for opioid withdrawal symptoms with a buprenorphine-containing medication that’s taken by mouth. But you’ll need to have received this medication for at least 7 days before starting Sublocade. Taking other opioids with Sublocade can increase your risk for serious side effects. These include respiratory depression , severe sleepiness, loss of consciousness, coma, and death. Sublocade may also make opioid pain relievers less effective at relieving pain. You should not drink alcohol or use street drugs during your treatment.
Sublocade vs. Suboxone
This is when you have long-term treatment with buprenorphine to help keep your cravings and withdrawal symptoms well managed. After you receive a dose of buprenorphine extended-release injection, you may notice a lump at the injection site for several weeks, but it should decrease in size over time. Be sure that your belt or waistband does not put pressure on the place where the medication was injected. Buprenorphine extended-release injection is only available through a special distribution program called Sublocade REMS. Your doctor and your pharmacy must be enrolled in this program before you can receive buprenorphine injection.
These lists contain examples of serious side effects that can occur with Sublocade, with Suboxone, or with both drugs . Suboxone also contains naloxone, am i an alcoholic although your body will absorb very little naloxone when you take Suboxone by mouth. Both Sublocade and Suboxone can cause very similar side effects.
- This is a condition in which your breathing becomes slow, shallow, weak, and may even stop.
- SUBLOCADE should not be administered to patients who have been shown to be hypersensitive to buprenorphine or any component of the ATRIGEL® delivery system .
- Because of this, taking the drug can make it more difficult to monitor the status of your head injury or brain problem.
- The overall adverse event profile was similar to the double-blind trial described above.
- Yes, please continue to the list of SUBLOCADE treatment providers.
These withdrawal symptoms may occur 1 month or longer after your last buprenorphine extended-release injection dose. The most common side effects from treatment with Sublocade include constipation, nausea, vomiting, headache, drowsiness, injection site pain, itching at the injection site and abnormal liver function tests. The safety and efficacy of Sublocade have not been established in children or adolescents less than 17 years of age. Clinical studies of Sublocade did not include participants over the age of 65.
Does Sublocade cause weight gain?
On the other hand, you shouldn’t take any opioid medications with Sublocade. And this could cause slowed breathing, loss of consciousness, changes in your heart rate, and even death. Sublocade can help reduce your opioid cravings and prevent opioid withdrawal symptoms if you stop taking opioids. A newly published study suggests the long-acting buprenorphine formulation BUP-XR is more effective than placebo in helping patients struggling with addiction to opioids. Once your cravings and withdrawal symptoms are managed, you can move to the maintenance phase of treatment. First, you’ll stop taking the form of buprenorphine by mouth.
Important Safety Information and Indication
It is your responsibility to select an HCP appropriate for your needs and you assume full responsibility for your interactions with any HCP you contact through the tool. Indivior is not responsible for the medical care or advice given by any participating HCP you choose to contact. Participating HCPs do not pay a fee to be listed in the tool, and their participation does not impose any requirements on the manner in which they treat or provide services to patients. The maximum number of patients that an HCP may treat is limited by law; therefore, some HCPs may not always be able to accept new patients. It should be removed from refrigeration 15 minutes before administering the injection to allow it time to warm up. Approximately 96% of buprenorphine is bound to plasma proteins.
Where will I be given Sublocade treatments?
(Benzodiazepines are drugs for anxiety or insomnia.) These side effects include respiratory depression , severe sleepiness, loss of consciousness, coma, and death. The effect of hepatic impairment on the pharmacokinetics of sublingual buprenorphine has been evaluated in a pharmacokinetic study. Inform patients that they may have detectable levels of buprenorphine for a prolonged period of time after treatment with SUBLOCADE. Considerations of drug-drug interactions, buprenorphine effects, and analgesia may continue to be relevant for several months after the last injection .
These QTc findings were all sporadic and transient and none led to aberrant ventricular rhythm. Review of ECG and adverse event data provided no evidence for syncope, seizure, or ventricular tachycardia or fibrillation. Fetal malformations and resorptions have also been reported following oral administration of 3 times the MDD of NMP delivered by SUBLOCADE at the MDD based on a body surface area comparison. Opioid-dependent women on buprenorphine maintenance therapy may require additional analgesia during labor. As with all opioids, use of buprenorphine prior to delivery may result in respiratory depression in the newborn.
Then the people were given buprenorphine taken under the tongue . After this, they were given an injection of Sublocade, followed by another Sublocade injection 4 weeks later. Researchers have looked into how effective Sublocade is in helping treat opioid use disorder. No, Sublocade injections contain only the drug buprenorphine. These lists contain examples of serious side effects that can occur with Sublocade, with Vivitrol, or with both drugs . Sublocade contains buprenorphine, and Vivitrol contains naltrexone.